Artistic Influences on Andreas Vesalius’s ‘De humani corporis fabrica libri septem’ and Its Influence on the Arts in the Sixteenth and Seventeenth Centuries

Posterior view of skeleton, Vesalius, de Fabrica

With the current exhibition at The Queen’s Gallery of Leonardo’s anatomical drawings, I thought it may be timely to look more closely at the study of anatomy by Renaissance artists, more specifically the collaborations between artists and anatomists publishing texts on the subject, and most specifically, the collaboration between Andreas Vesalius and artists in Titian’s studio.

Vesalius’s De humani corporis fabrica libri septem of 1543 has been recognised as an achievement not only of modern medical science, but also of extraordinary aesthetic value, representing Renaissance artists’ study and understanding of human anatomy as well as the perfection of the technical aspects of printing and typography. William Ivins has gone so far as to suggest that were it not for its masterful illustrations and superb printing, Veslaius’s work may be no more memorable than other sixteenth century anatomy texts, such as those produced by Massa, or Eustachius, whose text was arguably more accurate but had less aesthetic appeal.[1] Vesalius himself played a decisive role in his book’s magnificent material form. Given the detailed scientific and intellectual information the anatomical plates convey, it is believed Vesalius worked very closely with his draughtsman in planning the Fabrica, and in some cases likely drew the images himself.[2] Shifts in the text from the personal pronoun ‘we’ to ‘I’ suggest such drawings as the ‘arterial man’ and ‘venous man’ originated from the physician’s own observational sketches.[3] Vesalius also ensured the highest quality materials and utmost care were used in the production of the Fabrica. He secured the best draughtsmen from Titian’s studio, the finest block cutters, and best printer, Johannes Oporinus of Basel.[4] The illustrations were of such importance to Vesalius that he delayed the printing of his work until all the wood blocks were completed and could be shipped together to Basel, where he remained for at least seven months to oversee the printing process and proofread the copies. [5] Why in Vesalius’s view was the book’s appearance so significant? His aesthetic imperative was inextricably linked to the scientific and philosophical content of the text, and to the audience for which it was intended. Vesalius sought to resurrect the Greeks’ direct observational approach to the study of anatomy, which had been superseded by reliance on textual authorities alone.[6] It is therefore fitting that the Fabrica’s illustrations are copied from nature, not from copies of nature found in books. Also, given Vesalius’s references to ‘the dignity and beauty of man’ – a sentiment Galen expressed in earlier Anatomies and tied quite specifically to the complexity and dexterity of the human hand and its abilities for making art – it is appropriate that the material aspects of Vesalius’s book and that the iconography in the author’s portrait reinforce the unique capabilities of the human hand, which set us apart from other animals.[7] Crude plates and printing could not make this point as clearly. Both in its philosophic underpinnings and its expert execution, the completed work is a testament to the successful collaboration among anatomists, artists, and printers, and the new use of artistic developments of the late quattrocento and cinquecento for scientific illustration.

An examination of the aesthetic characteristics of Vesalius’s Fabrica, as distinct from its impact on medical science, will show to what extent Vesalius’s masterpiece was a product of renaissance developments in art theory and practice and to what extent the Fabrica, in turn, influenced artists in the sixteenth and seventeenth centuries. Martin Kemp has pointed out that, ‘the influence of the Fabrica upon the art world has yet to be charted,’ despite the evidence that demonstrates its value ‘as a source book for artists until the early nineteenth century’.[8] Since there is much speculation and debate surrounding the production of both the text and the illustrations of the Fabrica, it is a difficult question to answer.[9] Nonetheless, this exploration may offer insight into the intellectual exchange between artists and men of science in Renaissance Italy, the increased role of anatomical study in the artist’s education, and the formation of the idea of the doctus artifex.  There are several direct links between the Fabrica and practicing artists in the sixteenth and seventeenth centuries, which relate to both the images and the text of the book. Also, there are many indirect and more generalised ways in which Vesalian influence affected artistic practices in the Renaissance and beyond.

While there were illustrated anatomy texts – in the form of manuscripts as early as the thirteenth century – it was not until Vesalius’s seminal work De humanis corporis fabrica published in 1543 that the most current artistic developments were fully utilized in medical literature.[10] Anatomical renderings in pre-Vesalian medical texts proved unsuccessful as didactic aids and were unremarkable for their artistic merit.  Two Venetian publications, Ketham’s Fasciculo di Medicina (1493) and Gabriele de Zerbi’s Liber Anathomiae Corporis Humani (1502) illustrate the failure of physicians to utilize imagery reflective of the naturalistic approach to the figure common among artists at that time.[11] Vesalius’s Fabrica marks the first published anatomy in which the new approach to science based on first-hand observation was coupled with this same observational approach in art. Also unlike previous anatomy books, text and illustration are interwoven in a meaningful and novel way in the Fabrica. The plates are labeled and explained in depth in marginal notes, as well as being referred to in the body of the text. In some of the subsequent pirated and authorized editions of the Fabrica, text and illustrations were produced separately. Omission of the images in some printings reflected the lingering traditional primacy of textual authority for the study of human anatomy.[12]

With the increased emphasis on direct observation in the sciences and the arts, the role of skilled draughtsmen to present this revolutionary view of the natural world became crucial. In the early sixteenth century, the Spaniard Gonzalo Fernàndez de Orviedo, while working on a natural history of the Indies, expressed regret that he did not have with him ‘Berruguete or some other excellent painter like him, or … Leonardo da Vinci or Andrea Mantegna, famous painters whom I knew in Italy’.[13] In defending his 1543 work on plant specimens De Historia Stripium, Leonard Fuchs wrote of the ability for images to ‘communicate information much more clearly than the words of even the most eloquent men’.[14] Regarding medical books, however, there was strong debate concerning the usefulness of graphic methods to teach anatomy. Vesalius’s contemporaries – most notably, Sylvius, Fernel, Guenther, Massa, Colombo, and Fallopia – did not use illustrations in their treatises, favouring the more traditional purely textual approach to the subject. Furthermore, several among them actively opposed anatomical drawings. Among the anatomists writing books in the sixteenth century, only Berengario da Carpi, Charles Estienne, and Eustachio included illustrations of the figure in their works.[15] Berengario acknowledged that in addition to the figurative woodcuts being useful for surgeons, they may also be used ‘to help artists in drawing the parts of the body,’ a note which accompanies the fifth figure in the series. Berengario also made a reference to ‘skilled painters’ who learned how to render the muscles correctly, but does not elaborate on their methods of instruction.[16] Vesalius made similar references to the use of his illustrations by artists, and as Michelangelo Muraro suggests, it is probably due to this segment of his intended audience that Vesalius gave so much importance to the illustrations for his work.[17] That a segment of his intended audience was artists may explain his desire to have aesthetically beautiful illustrations, but he was also capitalizing on the accuracy that the print medium made possible in hopes of educating practicing physicians. Print publishing allowed for a hitherto unknown level of consistency and accuracy that had obvious advantages for spreading scientific information and disseminating it to an audience that not only included specialists, but also ‘eruditi viri’, a class that increasingly overlapped with artists in the Renaissance.[18]

Before examining the impact Vesalius’s work had on artistic theory and practice in the sixteenth and seventeenth centuries, it is necessary to consider the contributions artists made to the Fabrica itself. Although there is much debate regarding who the artist responsible for the plates in the Fabrica was, most scholars identify Jan Stephan van Calcar, a student in Titian’s workshop, as the draughtsman of at least several plates. Based on both documentary evidence and stylistic tendencies, Martin Kemp presents a compelling case for attribution of the ‘muscle-men’ to Calcar.[19] Calcar’s involvement as the draughtsman for anatomical illustrations for Vesalius was first mentioned in the second edition of Vasari’s great work Vite de piu eccelenti pittori (1568). In crediting Calcar with ‘the designs that the excellent Andreas Vesalius caused to be engraved and issued’, Vasari did not mention for which of Vesalius’s three published works these drawings were produced, which leaves sufficient doubt regarding attribution of the plates in the Fabrica. In his Venesection letter, Vesalius himself wrote of Calcar’s involvement in his plans for his great anatomical work: ‘if bodies become available and Joannes Stephanus [of Calcar], the distinguished contemporary artist, does not refuse his services, I shall certainly undertake the task [of publication]’.[20] It is unknown whether there was collaboration on the designs for the plates – perhaps with Titian himself – but given the practices of Titian’s studio, it is possible, as Michelangelo Muraro suggests, that the hands of several artists, including the master himself, worked on the drawings.[21] If the illustrations had been exclusively the work of Titian, it seems likely there would have been some reference identifying the artist in the Fabrica – as there is to Oporinus – since, as Martin Kemp points out, his involvement would have been a major selling point for the book. Another possibility is that evidence of another hand at work in these illustrations could be that of the artisan who transferred the drawings and carved the wood blocks for printing, since there is no evidence whether Jan Stephen performed this task himself and no other known wood blocks from him survive. The landscapes, which are the setting for the Vesalian muscle-men, are attributed to yet another artist. Muraro identifies him as Domenico Campagnola, and also attributes the male and female nude figures to Jacopo Sansovino, and posits Titian’s direct involvement in creating some of the illustrations.[22]

Fifth muscle-man, Vesalius, de Fabrica

Sixth muscle-man, Vesalius, de Fabrica

The draughtsmen who worked on the Fabrica were not the only ones who contributed to the book’s exquisite material form: the block-cutters and printer deserve credit for its successful outcome.  A certain technological advance in the creation of woodcuts allowed for the delicate and precise linework in the plates. The pear wood blocks were boiled in linseed oil to allow block cutters to achieve similar results to those which wood engraving yields.[23] Generally with woodcuts, because they are not carved into the end grain of the wood block, they are incapable of representing highly detailed images like those in the Fabrica. The technique of using linseed oil on the blocks made them harder and able to accept much more refined linework.

While there were many excellent printers in Venice, Vesalius chose to have his work produced in Basel by Johannes Oporinus. This decision required the woodblocks, which had been carved in Venice to be transported across the Alps. Basel rivaled Venice at this time for its mastery of the printing medium, and Oporinus had many personal qualities that made him an ideal printer by Veslaius’s estimation. He was the son of a printer and grew up in an artistic climate, and his skill and artistry in the craft of printing was matched by his scholarly and humanist pursuits.[24] He had been known to take on controversial or even heretical projects and the unorthodox views expressed in the Fabrica likely appealed to him.[25] As a young scholar, he accompanied the anatomist Paracelsus for several years in order to gain medical knowledge.[26] This experience, which he documented in his letters, made him uniquely suited to print the Fabrica with every consideration, whether aesthetic, technical, or scientific.

In addition to those artists and artisans like Jan Stephan van Calcar and Johannes Oporinus, who had a direct hand in creating the Fabrica, there are many indirect artistic influences evident in the work. The dissection scene on the title page borrows from a Donatello drawing. The schema of the cadaver flanked by pressing crowds that Donatello created also influenced two other medical texts, both of which were published in Venice, the 1493 Venetian publication by Ketham Fasciculo di medicina and the mid-cinquecento text by Colombo De re anatomica.[27] The layout and structure are taken from Serlio’s architectural treatise of 1537. And as the architect responsible for the construction of such wooden theatres as the one depicted on the Fabrica’s title page, Serlio has another connection to the anatomy book.[28] Serlio and Vesalius were in close proximity to one another, both living in Venice in the 1530’s while working on their respective didactic books. Serlio trained in a painter’s workshop and associated with Titian’s circle of painters and humanists. It is likely Vesalius knew Serlio’s book and took ideas about the illustrations for his work from it.[29]  Another artwork that seems to have influenced one of the Vesalian plates is the Belvedere Torso. William Ivins remarks on similarities between the Belvedere Torso and Vesalius’s illustration of the abdomen, but adds that he is uncertain whether Vesalius had an interest in Antique art and whether the Belvedere Torso had been copied and circulated at the time the Fabrica was being produced.[30] Several drawings of the statue had indeed been made in 1500, and it was popular among artists who were eager to translate and reproduce works from Classical Rome.[31]  Also, as to Vesalius’s interest in Antique art, it is noteworthy that both Galen and Vesalius refer to Polyclitus, the ancient sculptor famous for his art treatise on beauty and symmetry, in their texts. This reference is at once an acknowledgement of classical artists’ contribution to the understanding of the human body and a demonstration of both authors’ philosophical approach to anatomical study that concerns the beauty and dignity of man.[32]

Vesalius’s illustrations borrowed from his contemporaries and the Ancients, but for the most part, their iconography differed from imagery in earlier medical texts. At the time the Fabrica was published the only anatomical drawings that exhibited comparable artistic merit to those in Vesalius’s book were Leonardo’s, but since they were unpublished and the two men were separated by time and geography, Charles Singer suggests it is unlikely these drawings had any bearing on Vesalius’s work.[33] However, it is possible that someone in Titian’s workshop or in Vesalius’s circle may have been familiar with these detailed anatomical studies by Leonardo. Despite being left unpublished at the time of his death, Leonardo left thousands of detailed drawings and notes to his pupil and heir Melzio, who made them available for study to a select group of men while he was attempting to compile them for publication, as his master had planned but never realised. The widespread knowledge of Leonardo’s anatomical work helped make dissections among artists an acceptable, and even laudable, practice. Vasari described Leonardo as ‘heretical’ for his dissections and use of cadavers, but by the time Vesalius and Calcar were working on the Fabrica, this method was firmly established.[34]  Furthermore, the artistic climate of the quattrocento and cinquecento gave rise to anatomical inquiry by and for artists for use in depicting the human figure in their works. Without these artistic forerunners, Veslaius would not have found suitable draughtsmen to execute his vision for his great work.

Artists were practicing dissection as early as the late fifteenth century. According to Vasari, Pallaiolo was dissecting bodies before Leonardo became engaged in the practice. In the literature of science and art, Vesalius was not the first author to regard dissection as the superior method for studying human anatomy. Paracelsus wrote of the ‘Book of the Body’, which can only be studied properly through comparison of its parts to nature.[35] Also, Berengario da Carpi, Alessandro Benedetti, Niccolò Massa, Johann Winther, and even Galen recommended direct observation as essential to anatomical study.[36] Artists too shared this belief in the supremacy of direct observation of nature for understanding form. As Condivi wrote of Michelangelo: ‘he, not from the labors of others, but from nature herself has wished to learn, setting her before himself as the true example’.[37] What began as a study for artistic purposes of depicting the figure accurately – particularly the figure in motion – developed into a mutually beneficial relationship between artists and physicians, in several cases. Leonardo famously worked with Marcantonio della Torre in Milan from 1506-1512, Michelangelo combined his efforts with Realdo Colombo, and Andrea del Sarto’s student Rosso Fiorentino, together with Perino del Vaga, was involved in the illustrated textbook compiled by Estienne and Rivière, just as Jan Stephen van Calkar was working with Vesalius.[38] Such publishing projects proliferated after 1600, but it was not exclusively to serve medical illustration that artists took up this depth of anatomical study.[39]

Prior to the publication of the Fabrica, theoretical writings intended for artists encouraged the study of anatomy. Art treatises like those of Cennini and Alberti reinforced the significance of anatomical study in an artist’s training and typically allied the discipline with accomplished draughtsmanship. In his 1548 work Da Pintura Antigua, Francisco de Hollanda asserted that ‘the worthy draughtsman’ must know anatomy ‘as a surgeon’, knowing not only the ‘outside surface’ of his subjects, but also what is ‘hidden and inside’.[40] Lamazzo also listed anatomy among the liberal arts and mentioned Vesalius ‘in a garbled way’ in his Trattato dell’arte pittura, scoltura, et architecttura, published in Milan in 1584.[41] Pacheo and Carducho are two seventeenth century Spanish authors who cite Vesalius specifically as helpful to arists’ particular needs. In his Arte de la Pintura, Francisco Pacheo wrote that Andreas Vesalius’s anatomy book provided images of a ‘número de músculos conveniente a la pintura’, but he also mentioned Valverde and Humusco, the student of the esteemed Realdo Colombo.[42] In these source books, the study of anatomical texts in general, and Vesalius’s Fabrica, in particular, were recommended readings for painters and sculptors. Vesalius intended his work to be used for this purpose. As Berengario had done before him, Vesalius stated in the Fabrica that the illustrations of the superficial muscles were designed in part to aid artists.[43] Accompanying the first ‘muscle-man’ is the following text:

“It has been my intention to leave this illustration, as well as the following, free of lettering so that it might not appear spotted to the observer, since the third [illustration] is really the first I prepared for teaching purposes, for the present one – but not the following – displays what we do not observe skillful painters and sculptors to emphasize often in muscular, and as it were, ideal representations of men. Those membranous markings seen on the face and neck of the third illustration and also the arrangement of the fibres in the muscles perplex the artist, sculptor, and modeler, whose studies it seems desirable to aid.”[44]

He continues this statement of intent to aid artists by recommending that they acquire in addition to knowledge of the superficial muscles, an understanding of the bones, and full comprehension of ‘the function of each muscle so that they may know when to depict a muscle as shorter, longer, more prominent, or compressed’.[45]

Although theory does not always follow workshop practice, there is evidence that books such as Vesalius’s were used for artistic training. Leonardo referred to an edition of Mondino in his notes, which was possibly the illustrated Venetian edition by Ketham.[46] In circumstances when cadavers were not available, books served as surrogates for anatomical study. Vasari wrote to the physician Baccio Rontini in 1537, asking him to bring ‘that book of bones and anatomy that I gave you’ to Arrezzo because corpses for dissection were more difficult to access there than they had been in Florence.[47] Vasari’s work could have been a manuscript or his own notebook or any number of printed anatomy texts, but it is significant that books functioned as artistic aids. The claim that artists used anatomy books as part of their research is curiously substantiated and contradicted with the same piece of evidence: Galenic errors in their illustrations. In the case of Leonardo, such incorrect inclusion of animal anatomy is used to argue that he possessed textual as well as experiential understanding of human anatomy. With John Stephan Calcar, similar erroneous elements in some of the Fabrica’s woodcuts have been presented as evidence that Vesalius himself must necessarily have been the one chiefly responsible for the illustrations on the basis that the flaws betrayed a knowledge of the textual authorities in the discipline.[48]

With the establishment of art academies in Italy in the sixteenth century, the study of anatomy became officially acknowledged as a necessary part of an artist’s training.  Medical books, along with statues from antiquity and bronze ecorchés, were used in the art academies, to aid anatomical study.[49] Based on the number of student copies of Veslaian illustrations, it seems likely that art academies owned copies of the Fabrica or Epitome, but inventories of these libraries do not exist to confirm this assumption. Two good examples of these student renderings are a copy of the second muscle figure from the Fabrica attributed to Allori, which is in the Louvre, and a late sixteenth-century or early seventeenth –century drawing of various Vesalian plates dispersed across a large sheet of paper, which is in a collection of anatomical drawings in the Biblioteca Comunale degli Intronati in Siena.[50] Also, images depicting anatomies carried out in the academies show the cadaver suspended with a rope and pulley in the method that Veslaius described in the Fabrica, which is further indication that Vesalius’s texts were familiar to academicians.[51] Although the Fabrica was published for the wide intellectual community, whether or not artists used this specific book for their erudition is unknown, with few exceptions. It is listed in the inventory of Velasquez’s books, but earlier than this mid-seventeenth century owner, there are only references to books on anatomy in artists’ libraries with no specific mention of either the Fabrica, or Vesalius.[52]

The good condition of extant copies of the Fabrica suggests it was considered a classic in its own time and was shelved rather than read.[53] As Andrea Carlino points out, Vesalius’s volume was too expensive to replace existing anatomy texts and subsequent sixteenth century anatomies were so closely modeled on Vesalius’s book that they became suitable substitutes, albeit largely plagiarized ones.[54] Far fewer copies of Vesalius’s Epitome, the abridged version of the Fabrica also published in 1543 by Oporinus, survive, suggesting greater wear and tear.[55] Possibly this work was more commonly used as a workshop copy.

It is unknown how many copies of the Fabrica were in circulation in the later sixteenth century. Based on wear to the woodblocks for its illustrations, it is estimated that between three thousand and four thousand prints were pulled from the blocks including one thousand five hundred for Leveling’s edition and the first and second editions of the Fabrica and Epitome combined.[56] More specific information regarding the number of copies printed in each edition is lacking. This number would not wholly represent the number of people with access to the book. Sharing books was common practice among artists and academicians. Also, as Vesalius himself writes, he is concerned about the number of pirated and plagiarized copies being produced. So, it is not possible to estimate the full extent of the book’s impact on the artistic and intellectual community for which it was written.

As artists began to participate in the intellectual sphere in humanist circles in the Renaissance, the Fabrica gained importance for painters and sculptors not only because they could use it in their studio practice, but also because they had scientific interests and aspirations.[57] Artists adapted the idea of the doctus poetica to their own profession, inventing the concept of the doctus artifex, or the ‘learned artist’. Books owned and used by artists for their work took on added significance given this humanist idea of what was involved in the artist’s education, which encompasses much more than the technical knowledge of medieval craft treatises.[58] There is evidence of artists belonging to literary academies in Italy although the academicians tended to favour men of letters, and artists had to prove their worth as wordsmiths rather than painters or sculptors.[59] Nevertheless, images remained the most powerful way for artists to contribute to the scientific and cultural dialogue. Concerning the Galenic backlash against Vesalian ideas, Titian, who knew Vesalius in Venice, produced a drawing caricaturising the famous classical statue, Laocoön, in which the anatomical perfection of the piece is transformed into apish figures in a visual critique of the Galenic view.[60]

The Fabrica’s influence on the arts transcended its use as a study aid and prized edition in artists’ libraries. The Fabrica supplied new iconography representing the humanist attitude toward the body. The title page of the Fabrica presents imagery that later sixteenth century anatomy texts adopted. The depiction of the physician-anatomist in the act of performing a dissection is significant, for Vesalius criticized the separation of theory and practice in the medical arts, claiming that discrediting manus opera led to the ruination of science. That the authoritative text is shown in the hands of the public rather than the physician’s is also a novel change in the depiction of dissection scenes.[61] In the title page of 1543 edition, two figures in the crowd of onlookers are represented with books in hand. Vesalius himself is shown performing a dissection, with medical instruments on the table beside the cadaver, and with his left hand pointing heavenward either indicating the skeleton above or in the quintessentially Platonic pose, while his right hand probes the cadaver in a demonstration of an Aristotelean approach to knowledge based in experiential understanding of phenomena. Perhaps through these hand gestures, which recall Raphael’s ‘School of Athens’ (1510-11), Veslaius is depicted as the embodiment of a new synthesis of these schools of philosophy.

Beyond the iconography of the title page, the illustrations of the skeletons and muscle men represent a new way of rendering the flayed figure in a manner of  ‘living anatomy’, in which the animated corpses are posing and gesturing and set in an Italian landscape. Ways of depicting the figure in motion were prefigured in the works of Leonardo, whose Treatise on Painting contained numerous chapters on the subject of movement and anatomy.[62] Juan Valverde de Hamusco, a physician who studied at Rome under both Realdo Colombo and Bartolomeo Eustachio, published his anatomical treatise Historia de la composicion del cuorpo humano in Rome in 1556, followed Vesalius’s work so closely, it may be considered plagiarism. In a letter to his readers, Valverde gave the following excuse for this flagrant copying:  ‘Although some of my friends were of the opinion that I should make new figures, without using those of Vesalius, I chose not to do so, to avoid the confusion that might have followed from it since then one would not have known so easily in what I agreed or disagreed with him’. [63]

Imitation was but one way in which Vesalius’s Fabrica influenced other anatomy texts and the artists producing illustrations. The more reactionary spirit of competition also drove artists to produce work that aimed to surpass Vesalius’s book. Michelangelo’s planned collaboration with the anatomist Realdo Colombo was one example of this reaction to the Fabrica’s illustrations, which at the time were attributed to Titian himself. Since Titian was not known for his skill at disegno, Michelangelo wished to produce the definitive book of anatomical drawings himself.[64] Colombo had assisted Vesalius at Padua, and when he met Michelangelo in 1547, the Vesalian-Galenic debates were very much in the intellectual atmosphere. Aware of the drama, the planned collaboration between Colombo and Michelangelo was at once an effort by the anatomist to correct the errors in both Galen and Vesalius, and by the artist ‘to challenge Titian’s shop with his unparalleled pictorial mastery of the human figure.[65]

As early as the fifteenth century, artists, independent from physicians, were developing an interest in anatomy to perfect their ability to draw the human form.[66] Vesalius’s vision to utilize this achievment in disegno in the service of science resulted in his masterfully crafted book, which in turn contributed to the world of artists and art academies. Given the existing interest in anatomy by artists at the time of the Fabrica’s publication, it was reasonable for Vesalius to assume that painters and sculptors would value it for their work. An engraved portrait of Vesalius by Philip Galle, published in 1572, is accompanied by a verse that suggests artists’ indebtedness to the physician: ‘This man added art to physicians, [and] added art also to painters…’.[67] In the documentary evidence that survives, the Fabrica is listed among several anatomies that may be useful to artists. Existing drawings that were copied from Calcar’s illustrations are further evidence of the Fabrica’s use as a teaching aid in art academies. In addition to be imitated in medical books, the Fabrica’s images were also reproduced in books of artistic anatomy. Though inventories of artists’ libraries in the sixteenth century do not exist to determine who specifically owned copies of the Fabrica, based on the widespread interest in human anatomy, the use of books by and for artistic study, the proliferation of authorized and pirated copies of Vesalius’s work, visual quotation from Calcar’s skeletons and muscle figures in the pictorial arts, and the fluid exchange of ideas characteristic of humanist society, it is inconceivable that Vesalius’s masterpiece did not influence artists in the sixteenth and seventeenth centuries.

Luo Ping (1733-1799), ink drawing based on Vesalius’s skeletal plates

1 William M. Ivins, Jr., ‘What About theFabrica of Vesalius?, in Three Vesalian Essays to Accompany the Icones Anatomicae of 1934 (New York: MacMillan, 1952), pp. 43-99 (p. 59).

2 Martin Kemp, ‘A Drawing for the Fabrica; And Some Thoughts Upon the Vesalian Muscle-men’, Medical History (1970), 277-288 (p. 282).

3 C. D. O’Malley, Andreas Vesalius of Brussels 1514-1564 (Berkeley: University of California Press, 1964), p. 127.

4 C. D. O’Malley, ‘Andreas Vesalius 1514-1564 In Memoriam’, Medical History, ed. by F. N. L. Poynter, 8 (1964), 299-308 (p. 303).

5 Walter Pagel and Pyarali Rattansi, ‘Vesalius and Paracelsus’, Medical History, ed. by F. N. L. Poynter, 8 (1964), 309-28 (p. 315).

6 Ludwig Edelstein, ‘Andreas Vesalius, the Humanist’, Bulletin of the History of Medicine, 14.5 (1943), 547-61 (p. 551).

7 Nancy G. Siraisi, Medicine and the Italian Universities 1250-1600 (Leiden: Brill, 2001), pp. 257-58.

8 Martin Kemp, p. 288.

9 C. D. O’Malley, Andreas Vesalius of Brussels 1514-1564, p. 124.

10 Charles Singer, and C. Rabin, A Prelude to Modern Science: Being a Discussion of the History, Sources, and Circumstances of the ‘Tabulae Anatomicae Sex’ of Andreas Vesalius (Cambridge: Cambridge University Press, 1946), p. xxxi.

11 Andrew Cunningham, The Anatomical Renaissance: The Resurrection of the Anatomical Projects of the Ancients (Adershot: Scolar Press, 1997), pp. 45, 60.

12 Nancy G. Siraisi, pp. 292-93

13 Pamela H. Smith and Paula Findlen, eds., Merchants and Marvels: Commerce, Science, and Art in Early Modern Europe (New York: Routledge, 2002), p. 7.

14 Pamela H. Smith and Paula Findlen, p. 8.

15 Charles Singer and C. Rabin, pp. iv-v.

16Roger French, Dissection and Vivisection in the European Renaissance (Aldershot: Ashgate, 1999), pp. 100-01.

17 Michelangelo Muraro, ‘Tiziano E Le Anatomie Del Vesalio’, in Università Degli Studi Di Venezia Convegno Di Studi Tiziano E Venezia (Venice: Neri Pozza Editore, 1976), pp. 307-16 (p. 307).

18 William M. Ivins, p. 49.

19 Martin Kemp, pp. 285-87.

20 O’Malley, Andreas Vesalius of Brussels 1514-1564, pp. 124-25.

21 Michelangelo Muraro, pp. 308-9.

22 Michelangelo Muraro, p. 308.

23 Willy Wiegrand, ‘Marginal Notes by the Printer of the Icones’, in Three Vesalian Essays to Accompany the Icones Anatomicae of 1934 (New York: MacMillan, 1952), pp. 27-42 (p. 32).

24 C. D. O’Malley, Andreas Vesalius of Brussels 1514-1564, p. 131.

25 C. D. O’Malley, Andreas Vesalius of Brussels 1514-1564, p. 133.

26 Walter Pagel and Pyarali Rattansi, pp. 309-10.

27 Bernard Schultz, Art and Anatomy in Renaissance Italy (Ann Arbor: UMI Research Press, 1985), p. 50.

28 Andrea Carlino Books of the Body: Anatomical Ritual and Renaissance Learning, trans. by John Tedeschi and Anne C. Tedeschi (Chicago: University of Chicago Press, 1999), p. 46.

29 Pamela O. Long, ‘Visual Representation and the Investigation of Nature’, in Merchants and Marvels: Commerce, Science, and Art in Early Modern Europe, ed. by Pamela H. Smith and Paula Findlen (New York: Routledge, 2002), pp. 74-78 (p. 74-76).

30 Wiliam M. Ivins, footnote on p. 90.

31 Francis Ames-Lewis The Intellectual Life of the Early Renaissance Artist (New Haven: Yale University Press, 2000), pp. 83-84.

32 Nancy Sirasi, p. 302.

33 Charles Singer, and C. Rabin, p. iii.

34 Kenneth D. Keele, ‘Leonardo’s Influence on Renaissance Anatomy’, Medical History, ed. by F. N. L. Poynter, 8 (1964), 360-70, p. 363.

35 Walter Pagel and Pyarali Rattansi, p. 316.

36 Andrea Carlino, p. 40.

37 David Summers, Michelangelo and the Language of Art (Princeton: Princeton University Press, 1981), p. 397.

38 Kenneth D. Keele, pp. 361, 369-70.

39 Monique Nicole Kornell, ‘Artists and the Study of Anatomy in Sixteenth Century Italy’ (unpublished doctoral thesis, University of London, Warburg Institute, 1993), p. 214.

40 Monique Nicole Kornell, p. 30.

41 Charles Hope, email communication, 13 April 2011.

42 Francisco Pacheo, Arte de la Pintura, ed. by Boneventura Bassegoda I Hugas (Madrid: Catedra Arte Grandes Temas, 1990), p. 384.

43 C. D. O’Malley, ‘Andreas Vesalius 1514-1564 In Memoriam’, Medical History, ed. by F. N. L. Poynter, 8 (1964), 299-308 (p. 303) and C. D. O’Malley, Andreas Vesalius of Brussels 1514-1564, p. 160.

44 O’Malley, Andreas Vesalius of Brussels 1514-1564, p. 160.

45 O’Malley, Andreas Vesalius of Brussels 1514-1564, p. 161.

46 Monique Nicole Kornell, p. 91.

47 Monique Nicole Kornell, p.89.

48 William Ivins, p. 94.

49 Roger French, p. 101.

50 Monique Nicole Kornell, p. 92.

51 Monique Nicole Kornell, p. 82-85.

52 Jan Bialostocki, ‘Doctus Artifex and the Library of the Artist in XVIth and XVIIth Century’, in De Arte et Libris Festschrift Erasmus 1934-1984 (Amsterdam: Erasmus Antiquariaat en Boekhandel, 1984), pp. 11-22 (p. 4).

53 C. D. O’Malley, ‘Andreas Vesalius 1514-1564 In Memoriam’, p. 304.

54 Andrea Carlino, p. 53.

55 O’Malley, ‘Andreas Vesalius 1514-1564 In Memoriam’, p. 304.

56 Willy Wiegrand, p. 32.

57 Francis Ames-Lewis, p. 61.

58 Jan Bialostocki, p. 11.

59 François Quiviger, ‘The Presence of Artists in Literary Academies’, in Italian Academies of the Sixteenth Century, 1995, p. 107.

60 Andrea Carlino, p. 51.

61 Andrea Carlino, pp. 40, 46.

62 Kenneth D. Keele, p. 367.

63 Andrea Carlino, p. 53-54.

64 David Summers p. 398.

65 Bernard Schultz, p. 102.

66 Bernard Schultz, p. 51.

67 Monique Nicole Kornell, p. 91.